Posted 21 December 2012 - 07:35 PM
Posted 21 December 2012 - 10:25 PM
Posted 23 December 2012 - 03:38 AM
Posted 23 December 2012 - 03:25 PM
Coffee in an mTOR stack has to have some off time or you won't have the rebound effect. And the same goes for exercise and IF, when not training and having the "feeding window" you get the rebound effect. If you have coffee while eating and resting from exercise you are not really mTOR stacking.
Does anyone have a different opinion? Would be an interesting subject.
Btw: chocolate is supposed to have some mTOR effects to I think. In that case it would probably be best to have the chocolate just before exercise. But I have only heard Dave talk about the three mTOR marks (coffee, exercise, IF and he only does the first and last )
Happy holidays, stay BP
Posted 23 December 2012 - 05:23 PM
Posted 23 December 2012 - 06:34 PM
Can you expand on what mTOR means? I tried only having coffee before and the fat gave me a stomach ache, not ideal, probably didn't mix with the intense athletic training, just hitting weights would prob be fine. Tried having nothing before, same prob just stomach growling and weakness during a time when performance is critical. For me, a scoop of protein 1/2hr before was easy on the stomach and staved of hunger, I think that what is being done dictates the variance in protocol.
Its a lot of information to read about, and I'm pretty novice in the area. This is what wiki say:
mTOR inhibitors, e.g. rapamycin, are already used to prevent transplant rejection. Rapamycin is also related to the therapy of glycogen storage disease (GSD). Some articles reported that rapamycin can inhibit mTORC1 so that the phosphorylation of GS(glycogen synthase) can be increased in skeletal muscle. This discovery represents a potential novel therapeutic approach for glycogen storage diseases that involve glycogen accumulation in muscle. Various natural compounds, including epigallocatechin gallate (EGCG), caffeine, curcumin, and resveratrol, have also been reported to inhibit mTOR when applied to isolated cells in culture; however, there is as yet no evidence that these substances inhibit mTOR when taken as dietary supplements.
Mammalian Target of Rapamycin (mTOR) is one of the body's protein synthesis regulators. MTOR functions as an energy sensor; it is activated when ATP levels are high and blocked when ATP levels are decreased (AMPK is activated when ATP decreases, which works antagonistically to mTOR).
The main energy-consuming process in the cell is protein synthesis. When mTOR is activated (high ATP levels sensed) protein synthesis is increased and when mTOR is suppressed (low ATP levels are sensed) protein synthesis is blunted. MTOR activation is vital for skeletal muscle hypertrophy.
Interestingly, mTOR is also a nutrient sensor of amino acid availability, specifically of leucine availability. Research has shown that regulation of mTOR by ATP and amino acids act independently through separate mechanisms (Dennis et al., 2001).
I need to read more about this its hard to understand the therms sometimes
Posted 14 January 2013 - 07:09 PM
Posted 14 January 2013 - 07:14 PM
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